Endothelium-Derived Relaxing Factor and Vascular Grafting
نویسندگان
چکیده
منابع مشابه
Endothelium-derived vascular relaxing factor.
A large number and variety of compounds (acetylcholine, adenosine diphosphate, adenosine triphosphate, arachidonic acid, bradykinin, Ca2+ ionophores, calcitonin gene-related peptide, histamine, hydralazine, substance P, thrombin, and vasoactive intestinal polypeptide) have been shown to relax arterial smooth muscle indirectly. The endothelium in muscular arteries from several species appears to...
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The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean±SD value of 2.3± 1.5 to 2.5± 1.5 ml/min/100 ml forearm tissue (n=25, p<0.05) in response to low dose (0.5 ng/min/100 ml forearm tissue) ET infusion and decreased to 1.78±1.3 and 1.1±0.9 ml/min/100 ml forearm tissue (p<0.001...
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The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggrega...
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ヒ トの動 脈硬化 は加齢 と ともに正 脂血症 者 に も起 こ る一 事実 か らみ て も明 らか な よ うに,動 脈 硬化 に関与 す る要因 は血清脂 質 を中心 として現 在考 え られ てい る ものだ けでな く,数 多 く存在 す る と思われ る.殊 に加 齢 とともに増減す るパ ラメー ターについ ては,そ れ ら がた とえ既 知の代 謝系 では あ って も動脈硬 化 との関連 を幅 広 く見 直す必 要が あ ろ うと思わ れ る.こ の よ うな 反 省 は 近 年 明 ら か と な った2~3の 実 験 事 実, Endotheline1,2), EDRF (endothelium-derived relaxing factor)3~9), homocysteine動 脈 硬化 症10~14)などの 新 知 見 に よ って,よ り現実 的 課 ...
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Many vasoactive agents stimulate release of an endothelium-derived relaxing factor (EDRF). EDRF stimulates cyclic guanosine 3',5'-monophosphate (cGMP) accumulation and relaxation of vascular smooth muscle in a manner similar to that produced by sodium nitroprusside. Endothelium and vascular smooth muscle were isolated from porcine, bovine, and rat thoracic aorta. The capacity of sodium nitropru...
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ژورنال
عنوان ژورنال: The International Journal of Artificial Organs
سال: 1990
ISSN: 0391-3988,1724-6040
DOI: 10.1177/039139889001301003